Team:Lethbridge Canada

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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
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You <strong>MUST</strong> have the following information on your wiki:
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<ul style="font-weight:normal;">
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<li>a team description</li>
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<li>project description</li>
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<li>safety information (did your team take a safety training course? were you supervised in the lab?)</li>
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<li>team attribution (who did what part of your project?)</li>
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{| style="color:#000000;background-color:#b5cde2;" cellpadding="6" cellspacing="3" border="0" bordercolor="#00FFFF" width="65%" align="center"
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!align="center"|[https://2012hs.igem.org/Team:Lethbridge_Canada Home]
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!align="center"|[https://2012hs.igem.org/Team:Lethbridge_Canada/The_Team The Team]
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!align="center"|[https://2012hs.igem.org/Team:Lethbridge_Canada/The_Project The Project]
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!align="center"|[https://2012hs.igem.org/Team:Lethbridge_Canada/Results Results]
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!align="center"|[https://2012hs.igem.org/Team:Lethbridge_Canada/Human_Practices Human Practices]
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!align="center"|[https://2012hs.igem.org/Team:Lethbridge_Canada/Notebook Notebook]
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!align="center"|[https://2012hs.igem.org/Team:Lethbridge_Canada/Safety Safety]
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|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
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|[[Image:Lethbridge_Canada_logo.png|200px|right|frame]]
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''Tell us more about your project.  Give us background.  Use this as the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
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|[[Image:Lethbridge_Canada_team.png|right|frame|Your team picture]]
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== '''Introduction''' ==
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|align="center"|[[Team:Lethbridge_Canada | Team Lethbridge_Canada]]
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| Insulin is a hormone produced by pancreatic beta cells that causes cell membranes to become more permeable to glucose. It helps regulate blood sugar levels in the body; more is secreted as more sugar enters the bloodstream after a meal is consumed. Insulin and glucagon (another pancreatic hormone that increases blood sugar levels) are partners in the negative feedback loop that control the body’s blood sugar concentration.
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!align="center"|[https://igem.org/Team.cgi?year=2012&division=high_school&team_name=Lethbridge_Canada Official Team Profile]
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Diabetes mellitus is a disease that is characterized by abnormally high blood glucose concentrations.  Animal cells need glucose for energy, and these cells absorb glucose from the bloodstream with the help of insulin. Diabetes mellitus occurs when the immune system attacks and destroys the pancreatic beta cells that produce insulin so not enough is produced (type 1) or when the body’s cells become resistant to the action of insulin (type 2).
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Our goal is to use the natural glucose detecting mechanism found in Escherichia coli and combine it with the human insulin producing gene to create a “prosthetic” pancreatic beta cell. The transcription of insulin will only begin when a change in glucose levels in the cell’s external environment stimulates a sensory transduction chain of events.There are two parts to our project:
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1) Construct 1 focuses on the glucose sensing and gene regulating mechanism. We will implement the global respressor Mlc in order to control the rate at which the insulin gene is transcribed.
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2) Construct 2 focuses on insulin production and release.
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===Team===
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=='''Attribution'''==
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Tell us about your team, your school!
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These people and institutions were vital in making the Lethbridge High School iGEM experience both possible and enjoyable:
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===Project===
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University of Lethbridge - use of facilities
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What are you working on this semester?
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Dr. Hans-Joachim Wieden - advising, arranging funding, and administration
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===Notebook===
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Kim Orr- advising, organizing, as well as planning the trip to Indiana for the Jamboree
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Show us how you spent your days.
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University of Lethbridge iGEM Team - guidance and assistance with laboratory procedures
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===Results/Conclusions===
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Isaac Ward - help in teaching students proper usage of the spectrophotometer
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What did you achieve over the course of your semester?
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Nathan Dawson - advising
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===Safety===
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Alvin Lee- advising
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What safety precautions did your team take? Did you take a safety training course? Were you supervised at all times in the lab?
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Ben Vuong- advising
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===Attributions===
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Justin Luu - advising
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Who worked on what?
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Sutherland Dube - advising, guidance, arranging lab times, and keeping everyone on the same page
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===Human Practices===
 
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What impact does/will your project have on the public? 
 
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===Fun!===
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What was your favorite team snack?? Have a picture of your team mascot?
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== '''Sponsors''' ==
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Latest revision as of 09:23, 17 June 2012

Home.JPG
Home The Team The Project Results Human Practices Notebook Safety



Introduction

Insulin is a hormone produced by pancreatic beta cells that causes cell membranes to become more permeable to glucose. It helps regulate blood sugar levels in the body; more is secreted as more sugar enters the bloodstream after a meal is consumed. Insulin and glucagon (another pancreatic hormone that increases blood sugar levels) are partners in the negative feedback loop that control the body’s blood sugar concentration.


Diabetes mellitus is a disease that is characterized by abnormally high blood glucose concentrations. Animal cells need glucose for energy, and these cells absorb glucose from the bloodstream with the help of insulin. Diabetes mellitus occurs when the immune system attacks and destroys the pancreatic beta cells that produce insulin so not enough is produced (type 1) or when the body’s cells become resistant to the action of insulin (type 2).


Our goal is to use the natural glucose detecting mechanism found in Escherichia coli and combine it with the human insulin producing gene to create a “prosthetic” pancreatic beta cell. The transcription of insulin will only begin when a change in glucose levels in the cell’s external environment stimulates a sensory transduction chain of events.There are two parts to our project:

1) Construct 1 focuses on the glucose sensing and gene regulating mechanism. We will implement the global respressor Mlc in order to control the rate at which the insulin gene is transcribed.

2) Construct 2 focuses on insulin production and release.

Attribution

These people and institutions were vital in making the Lethbridge High School iGEM experience both possible and enjoyable:

University of Lethbridge - use of facilities

Dr. Hans-Joachim Wieden - advising, arranging funding, and administration

Kim Orr- advising, organizing, as well as planning the trip to Indiana for the Jamboree

University of Lethbridge iGEM Team - guidance and assistance with laboratory procedures

Isaac Ward - help in teaching students proper usage of the spectrophotometer

Nathan Dawson - advising

Alvin Lee- advising

Ben Vuong- advising

Justin Luu - advising

Sutherland Dube - advising, guidance, arranging lab times, and keeping everyone on the same page






Sponsors

Sponsors 00112.jpg

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