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| Established in 1958, [http://www.iitb.ac.in IIT Bombay] is one of the most recognized centers of academic excellence in the country today. The excellence of its academic programs, a robust  research and development program with  parallel improvement in facilities and infrastructure have kept it at par with the best institutions in the world. The ideas on which such institutes are built evolve and change with national aspirations, national perspectives, and global trends. At IIT Bombay we are continuously seeking to extend the boundaries of our research in a sustained manner with clear cut executable goals, grounded solidly in national realities.
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This is our first year of participation and as such, we are pretty excited about the prospects. We are a group of students from the Chemical Engineering Department and from the School of Biosciences & Bioengineering. The most exciting aspect that we found about this competition was the interdisciplinary learning. A chemical reactor system invariably involves the design of control structures, and it is the design of these structures in a biological system that we wish to attain via our project.
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A major objective of synthetic biology is to unveil the inherent design principles prevailing in biological circuits. Multiple feedback loops (having both positive and negative regulation) are highly prevalent in biological systems. The relevance of such a design in biological systems is unclear. Our team has used synthetic biology approaches to answer these questions. Our team comprises of nine undergraduates, three graduate students as student mentors and two faculty mentors, one each from biology and engineering background. The project specifically deals with the analysis of the effect of single and multiple feedback loops on gene expression. This project involves theoretical and experimental studies. We have designed synthetic constructs to mimic multiple feedbacks. The focus of our experimental work is to visualize the effect of multiple feedback loops on the synthetic construct using single cell analysis. The project provides insights into the roles of multiple feedback loops in biological systems.
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Revision as of 18:34, 18 May 2012

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Introduction

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Suspendisse eleifend sagittis bibendum. Etiam sit amet ante eros. Pellentesque et lorem lacus, a ullamcorper nisl. Fusce hendrerit, leo ut pharetra rutrum, odio leo ultrices est, non pulvinar velit purus vel urna. Lorem ipsum dolor sit amet, consectetur adipiscing elit. In hac habitasse platea dictumst. Donec gravida elementum libero ac interdum. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Quisque in felis elit. Nulla viverra nisi eget augue pellentesque laoreet. Nullam lorem ante, consectetur ut congue eget, lobortis at ligula. Fusce interdum molestie consectetur. Ut lectus est, lobortis ac imperdiet sit amet, varius eget orci. In hac habitasse platea dictumst. Nulla at nibh ut massa malesuada faucibus. Integer diam magna, commodo non iaculis id, tempor in tellus.

Duis feugiat commodo ultricies. Sed et elit quis nunc mattis elementum non id eros. Nam faucibus pharetra mauris ac laoreet. Nunc quis turpis nisi. Praesent convallis nibh ac nibh pulvinar vel pulvinar libero varius. Vivamus molestie, tellus eu iaculis sagittis, turpis massa consequat massa, in vestibulum dui enim commodo felis. Praesent non magna eget mauris aliquet facilisis hendrerit nec mi. Aliquam metus enim, luctus in egestas a, eleifend sed ligula. Etiam viverra libero eget tortor mollis et rhoncus enim consectetur. Suspendisse porttitor ipsum vel nibh blandit in volutpat augue accumsan. Nam odio arcu, aliquet vel malesuada tincidunt, tempor in sem. Pellentesque ipsum neque, scelerisque nec auctor quis, consequat sit amet leo. Praesent nec aliquam metus. Proin cursus odio nec magna dapibus eget accumsan nunc tempor. Suspendisse ac lacus dapibus augue ultrices gravida a vitae enim.

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